1-(1-enyl-stearoyl)-gpe (p-18:0)* to 1-linoleoyl-gpe (18:2)*

Numerator Metabolite

Metabolite Accession: GCST90199910
Name: 1-(1-enyl-stearoyl)-gpe (p-18:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.390
Position:
61588305
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
-20.171
Reference Allele:
A
-log10(P):
-206.676
MAF:
0.343
Beta (Num):
-0.112
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.278
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen synthesis, Ether lipid metabolism.4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleate metabolism.5[1], 6[2]

Ratio Explanation:

The ratio likely reflects FADS activity; linoleic acid (in the denominator) is a substrate for desaturation, so a lower ratio could suggest higher enzyme activity.1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid levels, which is associated with the risk of various inflammatory and metabolic diseases, including valvular heart disease, asthma, and type 2 diabetes.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data