1-(1-enyl-stearoyl)-gpe (p-18:0)* to 1-oleoyl-gpe (18:1)

Numerator Metabolite

Metabolite Accession: GCST90199910
Name: 1-(1-enyl-stearoyl)-gpe (p-18:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-oleoyl-gpe (18:1)
Metabolite Accession: GCST90199794
Name: 1-oleoyl-gpe (18:1)
Hmdb Id: HMDB0011506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PYVRVRFVLRNJLY

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.189
Position:
61557803
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-9.570
Reference Allele:
T
-log10(P):
-48.292
MAF:
0.346
Beta (Num):
-0.115
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.075
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis5[1], 6[2]

Denominator Metabolite Explanation:

Lysophospholipid metabolism, Glycerophospholipid metabolism7[1], 8[2]

Ratio Explanation:

This ratio reflects the activity of FADS enzymes. FADS1 and FADS2 are involved in the synthesis of precursor fatty acids for both plasmalogens and glycerophosphoethanolamines.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 and FADS2 are associated with altered polyunsaturated fatty acid levels, impacting the composition of various lipids, including those in the ratio.9[1], 1[2], 2[3], 4[4] This alteration in lipid metabolism is linked to an increased risk for cholelithiasis and disorders of lipoprotein metabolism.10[5], 11[6], 12[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data