1-(1-enyl-stearoyl)-gpe (p-18:0)* to 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*

Numerator Metabolite

Metabolite Accession: GCST90199910
Name: 1-(1-enyl-stearoyl)-gpe (p-18:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*
Metabolite Accession: GCST90200061
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*
Hmdb Id: HMDB0011342
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZVVYJAAMWXATNY

Associated Genomic Regions

Region: rs174544

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.180
Position:
61567753
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-10.132
Reference Allele:
C
-log10(P):
-53.877
MAF:
0.301
Beta (Num):
-0.122
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.058
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen synthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen synthesis.5[1], 7[2], 8[3], 9[4]

Ratio Explanation:

The ratio reflects FADS1-mediated desaturase activity, which alters the balance of saturated (18:0) versus unsaturated (18:1) fatty acyl chains available for plasmalogen synthesis.10[1], 11[2], 2[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters PUFA metabolism, reflected in the plasmalogen ratio.10[1], 12[2], 13[3], 2[4] This dysregulation impacts inflammation and lipid profiles, contributing to phenotypes like hypercholesterolemia, asthma, and phlebitis by affecting membrane composition and inflammatory mediator production.14[5], 11[6], 15[7], 16[8], 17[9]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data