1-(1-enyl-stearoyl)-gpe (p-18:0)* to 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)

Numerator Metabolite

Metabolite Accession: GCST90199910
Name: 1-(1-enyl-stearoyl)-gpe (p-18:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.320
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
-15.217
Reference Allele:
A
-log10(P):
-118.725
MAF:
0.343
Beta (Num):
-0.112
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.207
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Ether phospholipid metabolism4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylinositol metabolism7[1], 8[2], 9[3], 10[4]

Ratio Explanation:

The ratio reflects the balance between ether phospholipid and phosphatidylinositol synthesis, potentially influenced by FADS desaturase activity on fatty acid precursors for both lipids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters PUFA metabolism, impacting the composition of complex lipids.11[1], 12[2], 13[3], 14[4] This dysregulation is associated with altered inflammatory responses and lipid profiles, contributing to the risk of cardiovascular diseases, type 2 diabetes, and inflammatory conditions like IBD.15[5], 16[6], 17[7], 18[8], 19[9], 20[10], 21[11]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data