1-(1-enyl-stearoyl)-gpe (p-18:0)* to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*

Numerator Metabolite

Metabolite Accession: GCST90199910
Name: 1-(1-enyl-stearoyl)-gpe (p-18:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.280
Position:
61557803
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-16.178
Reference Allele:
T
-log10(P):
-133.870
MAF:
0.346
Beta (Num):
-0.115
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.165
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism, glycerophospholipid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Ether lipid metabolism, glycerophospholipid metabolism.7[1]

Ratio Explanation:

This ratio contrasts a plasmalogen with a saturated C18:0 fatty acid against one containing polyunsaturated C18:2, reflecting the desaturase activity of FADS enzymes.8[1], 9[2], 10[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetically determined FADS1 activity, indicated by eQTL colocalization, alters the synthesis of polyunsaturated fatty acids that are incorporated into plasmalogens.9[1], 11[2] This dysregulation of lipid metabolism is linked to phenotypes like cholelithiasis, hypercholesterolemia, and inflammatory disorders such as asthma and dermatitis.12[3], 13[4], 14[5], 15[6], 16[7], 17[8]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data