1-(1-enyl-stearoyl)-gpe (p-18:0)* to 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*

Numerator Metabolite

Metabolite Accession: GCST90199910
Name: 1-(1-enyl-stearoyl)-gpe (p-18:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.244
Position:
61588305
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
-12.010
Reference Allele:
A
-log10(P):
-74.838
MAF:
0.343
Beta (Num):
-0.112
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.131
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis5[1]

Denominator Metabolite Explanation:

Phosphatidylinositol biosynthesis6[1], 7[2]

Ratio Explanation:

The ratio reflects FADS1/FADS2 activity, where lower activity decreases stearoyl desaturation, impacting the balance between specific plasmalogens and phosphatidylinositols.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

FADS1/FADS2 gene variants influence PUFA metabolism, affecting levels of inflammatory precursors.1[1], 2[2], 8[3] This altered inflammatory state is linked to a higher risk of inflammatory bowel disease, which is also associated with changes in cholesterol and lipoprotein metabolism.9[4], 10[5], 11[6], 12[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data