1-(1-enyl-stearoyl)-gpe (p-18:0)* to dihomo-linolenoyl-choline

Numerator Metabolite

Metabolite Accession: GCST90199910
Name: 1-(1-enyl-stearoyl)-gpe (p-18:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of dihomo-linolenoyl-choline
Metabolite Accession: GCST90200090
Name: dihomo-linolenoyl-choline
Hmdb Id: HMDB0240646
Super Pathway: NA
Sub Pathway: NA
Inchikey: CPIZQONKXRTJBX

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.202
Position:
61581764
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-9.469
Reference Allele:
T
-log10(P):
-47.318
MAF:
0.308
Beta (Num):
-0.125
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.077
SE (Den):
0.018
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism

Denominator Metabolite Explanation:

Fatty acid metabolism.4[1], 5[2]

Ratio Explanation:

This ratio compares a stable ether phospholipid to a choline ester of DGLA, reflecting FADS1 enzyme activity which metabolizes the fatty acid in the denominator.6[1], 3[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters its desaturase activity, impacting the balance of pro-inflammatory and pro-resolving lipids derived from fatty acids like DGLA.6[1], 7[2], 8[3] This metabolic shift is linked to inflammatory and cardiovascular phenotypes like asthma, dermatitis, hypercholesterolemia, and thrombosis.2[4], 9[5], 8[6], 10[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data