n-oleoyltaurine to 3-hydroxyoctanoate

Numerator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Denominator Metabolite

Structure of 3-hydroxyoctanoate
Metabolite Accession: GCST90199680
Name: 3-hydroxyoctanoate
Hmdb Id: HMDB0001954
Super Pathway: NA
Sub Pathway: NA
Inchikey: NDPLAKGOSZHTPH

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.304
Position:
46870761
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
14.128
Reference Allele:
C
-log10(P):
-102.679
MAF:
0.213
Beta (Num):
0.239
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.065
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid amide metabolism, endocannabinoid signaling.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.8[1], 9[2], 10[3], 11[4]

Ratio Explanation:

The ratio likely reflects FAAH activity; reduced function impairs n-oleoyltaurine degradation, increasing its level relative to the beta-oxidation intermediate 3-hydroxyoctanoate.1[1], 2[2], 5[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided. The FAAH missense variant likely drives the ratio by decreasing n-oleoyltaurine hydrolysis, but a link to a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data