n-oleoyltaurine to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.256
Position:
46870761
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
14.239
Reference Allele:
C
-log10(P):
-104.259
MAF:
0.213
Beta (Num):
0.239
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.017
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid amide metabolism.1[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Ratio Explanation:

The ratio reflects FAAH-mediated hydrolysis of n-oleoyltaurine.8[1], 9[2] Reduced FAAH activity would increase the ratio by decreasing the degradation of n-oleoyltaurine.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype data is provided, so a direct link cannot be established. However, FAAH function is linked to pain perception, anxiety, and inflammation.2[1], 3[2], 4[3]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data