n-oleoyltaurine to octadecanedioate (c18-dc)

Numerator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Denominator Metabolite

Structure of octadecanedioate (c18-dc)
Metabolite Accession: GCST90199805
Name: octadecanedioate (c18-dc)
Hmdb Id: HMDB0000782
Super Pathway: NA
Sub Pathway: NA
Inchikey: BNJOQKFENDDGSC

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.248
Position:
15979744
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
12.711
Reference Allele:
C
-log10(P):
-83.555
MAF:
0.300
Beta (Num):
0.086
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.161
SE (Den):
0.017
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid amide metabolism5[1], 6[2]

Denominator Metabolite Explanation:

Dicarboxylic acid metabolism, Fatty acid omega-oxidation7[1], 8[2]

Ratio Explanation:

The ratio reflects competing fates for fatty acids. Increased CYP4F2 activity may favor omega-oxidation to octadecanedioate over conjugation to n-oleoyltaurine.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced CYP4F2 function may decrease the metabolism of pro-inflammatory mediators and alter fatty acid profiles, contributing to atherosclerosis and ischemic heart disease.9[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data