n-oleoyltaurine to hexadecanedioate (c16-dc)

Numerator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Denominator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.182
Position:
15979744
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
10.321
Reference Allele:
C
-log10(P):
-55.833
MAF:
0.300
Beta (Num):
0.086
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.095
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

N-acyl taurine biosynthesis, lipid signaling.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects competing fatty acid metabolism; CYP4F2's role in omega-oxidation produces hexadecanedioate, while its potential impact on oleic acid availability could influence n-oleoyltaurine levels.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

CYP4F2 polymorphisms influence its function in metabolizing lipids like arachidonic acid and vitamin K, which affects inflammation and vascular function, processes central to coronary atherosclerosis and ischemic heart disease.10[1], 11[2], 12[3] This altered lipid metabolism is reflected in the metabolite ratio.

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data