n-oleoyltaurine to (r)-3-hydroxybutyrylcarnitine

Numerator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Denominator Metabolite

Structure of (r)-3-hydroxybutyrylcarnitine
Metabolite Accession: GCST90199930
Name: (r)-3-hydroxybutyrylcarnitine
Hmdb Id: HMDB0013127
Super Pathway: NA
Sub Pathway: NA
Inchikey: UEFRDQSMQXDWTO

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.299
Position:
46870761
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
14.550
Reference Allele:
C
-log10(P):
-108.764
MAF:
0.213
Beta (Num):
0.239
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.060
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

N-acyltaurine metabolism, endocannabinoid signaling.7[1], 8[2], 9[3], 6[4]

Denominator Metabolite Explanation:

Ketone body metabolism, fatty acid beta-oxidation.10[1], 11[2], 12[3]

Ratio Explanation:

This ratio may reflect a metabolic shift between fatty acid signaling (numerator) and fatty acid oxidation/ketone metabolism (denominator), potentially modulated by FAAH activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided, so a direct link between the gene, metabolite ratio, and a specific phenotype cannot be established from the available data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data