n-oleoyltaurine to octadecenedioylcarnitine (c18:1-dc)*

Numerator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Denominator Metabolite

Structure of octadecenedioylcarnitine (c18:1-dc)*
Metabolite Accession: GCST90199970
Name: octadecenedioylcarnitine (c18:1-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CYPBWZKNUDFJJE

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.236
Position:
15979744
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
11.668
Reference Allele:
C
-log10(P):
-70.766
MAF:
0.300
Beta (Num):
0.086
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.149
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

N-acyl taurine biosynthesis, Lipid signaling.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation, Acylcarnitine metabolism.6[1], 10[2], 11[3]

Ratio Explanation:

The ratio reflects oleic acid partitioning. Decreased CYP4F2 activity may reduce omega-oxidation (denominator) while shifting substrate towards N-oleoyltaurine synthesis (numerator), altering their balance.12[1], 13[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced CYP4F2 activity, indicated by the altered ratio, is linked to coronary atherosclerosis.14[1], 15[2], 16[3] This may be due to its role in producing 20-HETE, a vasoactive molecule, thereby contributing to the development of ischemic heart disease.4[4], 17[5]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data