n-oleoyltaurine to hexadecenedioate (c16:1-dc)*

Numerator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Denominator Metabolite

Structure of hexadecenedioate (c16:1-dc)*
Metabolite Accession: GCST90200164
Name: hexadecenedioate (c16:1-dc)*
Hmdb Id: HMDB0304377
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.168
Position:
15979744
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
8.188
Reference Allele:
C
-log10(P):
-35.865
MAF:
0.300
Beta (Num):
0.086
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.081
SE (Den):
0.017
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid N-acyl taurine biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.4[1], 7[2]

Ratio Explanation:

This ratio may reflect a shift in fatty acid metabolism, where altered CYP4F2 activity decreases omega-oxidation (denominator) relative to N-acyl taurine synthesis (numerator).

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A CYP4F2 variant may reduce omega-oxidation of fatty acids, altering the ratio and impacting levels of bioactive lipids like 20-HETE, which regulates vascular function. This genetic alteration is linked to an increased risk of atherosclerosis and ischemic heart disease.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data