n-oleoyltaurine to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.269
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
15.709
Reference Allele:
C
-log10(P):
-126.370
MAF:
0.213
Beta (Num):
0.239
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.030
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs2338201

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.148
Position:
151845650
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
10.262
Reference Allele:
C
-log10(P):
-55.214
MAF:
0.395
Beta (Num):
0.023
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.125
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC LINGO4

LLM Analysis

Numerator Metabolite Explanation:

N-acyl taurine biosynthesis / Fatty acid amide metabolism.8[1], 9[2], 10[3]

Denominator Metabolite Explanation:

Fatty acid metabolism / beta-oxidation.11[1], 12[2]

Ratio Explanation:

Reduced FAAH activity increases n-oleoyltaurine (numerator) by decreasing its breakdown. The effect on tetradecadienoate (denominator) is not directly catalyzed by FAAH.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data