n-oleoyltaurine to stearate (18:0)

Numerator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.271
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
16.021
Reference Allele:
C
-log10(P):
-131.345
MAF:
0.213
Beta (Num):
0.239
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.032
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.147
Position:
102075479
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-8.060
Reference Allele:
G
-log10(P):
-34.809
MAF:
0.178
Beta (Num):
-0.050
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
0.097
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid amide metabolism.

Denominator Metabolite Explanation:

Fatty acid biosynthesis.4[1], 5[2]

Ratio Explanation:

The ratio of n-oleoyltaurine to stearate may reflect the rate of FAAH-mediated hydrolysis of n-oleoyltaurine relative to the availability of stearate for other pathways.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH activity, indicated by the missense variant and eQTL data, may lead to an accumulation of n-oleoyltaurine.6[1], 7[2], 8[3] Both n-oleoyltaurine and stearate metabolism are linked to cardiovascular phenotypes, suggesting the altered ratio due to genetic factors contributes to the observed disease associations.9[4], 10[5], 11[6], 12[7], 13[8]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data