oleoyl-linoleoyl-glycerol (18:1/18:2) [2] to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Structure of oleoyl-linoleoyl-glycerol (18:1/18:2) [2]
Metabolite Accession: GCST90199914
Name: oleoyl-linoleoyl-glycerol (18:1/18:2) [2]
Hmdb Id: HMDB0007219
Super Pathway: NA
Sub Pathway: NA
Inchikey: BLZVZPYMHLXLHG

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs174533

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.321
Position:
61549025
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
17.895
Reference Allele:
G
-log10(P):
-163.227
MAF:
0.339
Beta (Num):
0.073
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.247
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerolipid metabolism, triacylglycerol biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

GPI-anchor biosynthesis, glycerophospholipid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects FADS-mediated conversion of oleoyl/linoleoyl precursors to arachidonoyl-containing lipids, indicating lower FADS activity is associated with higher levels of this ratio.2[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters PUFA balance, increasing precursors (numerator) over products (denominator). This imbalance is linked to dyslipidemia and cholelithiasis, potentially through effects on cholesterol metabolism and inflammation.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data