oleoyl-linoleoyl-glycerol (18:1/18:2) [2] to 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)

Numerator Metabolite

Structure of oleoyl-linoleoyl-glycerol (18:1/18:2) [2]
Metabolite Accession: GCST90199914
Name: oleoyl-linoleoyl-glycerol (18:1/18:2) [2]
Hmdb Id: HMDB0007219
Super Pathway: NA
Sub Pathway: NA
Inchikey: BLZVZPYMHLXLHG

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Metabolite Accession: GCST90200045
Name: 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Hmdb Id: HMDB0009003
Super Pathway: NA
Sub Pathway: NA
Inchikey: ANRKEHNWXKCXDB

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.295
Position:
61592362
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
17.938
Reference Allele:
A
-log10(P):
-163.998
MAF:
0.346
Beta (Num):
0.071
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.224
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerolipid metabolism6[1], 7[2], 8[3], 9[4]

Denominator Metabolite Explanation:

Phospholipid metabolism10[1], 11[2], 12[3], 13[4]

Ratio Explanation:

The ratio reflects the relative activity of pathways producing triacylglycerols versus phosphatidylethanolamines, influenced by FADS1/2 enzyme activity on fatty acid precursors.1[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters fatty acid desaturation, influencing the lipid profile.1[1], 4[2], 5[3] This altered lipidome, specifically the balance of different polyunsaturated fatty acids, is associated with hypercholesterolemia and an increased risk for cholelithiasis.14[4], 15[5], 16[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data