oleoyl-linoleoyl-glycerol (18:1/18:2) [2] to 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*

Numerator Metabolite

Structure of oleoyl-linoleoyl-glycerol (18:1/18:2) [2]
Metabolite Accession: GCST90199914
Name: oleoyl-linoleoyl-glycerol (18:1/18:2) [2]
Hmdb Id: HMDB0007219
Super Pathway: NA
Sub Pathway: NA
Inchikey: BLZVZPYMHLXLHG

Denominator Metabolite

Structure of 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*
Metabolite Accession: GCST90200065
Name: 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*
Hmdb Id: HMDB0009012
Super Pathway: NA
Sub Pathway: NA
Inchikey: XYYHNDVKALDFHQ

Associated Genomic Regions

Region: rs174547

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.144
Position:
61570783
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
8.436
Reference Allele:
T
-log10(P):
-37.959
MAF:
0.340
Beta (Num):
0.072
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.072
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Diacylglycerol biosynthesis5[1]

Denominator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis6[1], 7[2]

Ratio Explanation:

The ratio reflects the balance between diacylglycerol and phosphatidylethanolamine synthesis, both influenced by the availability of polyunsaturated fatty acids modulated by FADS enzymes.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter the availability of fatty acids like oleic and linoleic acid, influencing the levels of both metabolites and potentially contributing to the risk of associated phenotypes like Cholelithiasis, Type 2 diabetes and Inflammatory bowel disease.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data