oleoyl-linoleoyl-glycerol (18:1/18:2) [2] to 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*

Numerator Metabolite

Structure of oleoyl-linoleoyl-glycerol (18:1/18:2) [2]
Metabolite Accession: GCST90199914
Name: oleoyl-linoleoyl-glycerol (18:1/18:2) [2]
Hmdb Id: HMDB0007219
Super Pathway: NA
Sub Pathway: NA
Inchikey: BLZVZPYMHLXLHG

Denominator Metabolite

Structure of 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*
Metabolite Accession: GCST90200079
Name: 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*
Hmdb Id: HMDB0009069
Super Pathway: NA
Sub Pathway: NA
Inchikey: PECSWFQRRFRZPW

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.194
Position:
61592362
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
10.197
Reference Allele:
A
-log10(P):
-54.547
MAF:
0.346
Beta (Num):
0.071
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.123
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Triacylglycerol biosynthesis

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The ratio reflects FADS1/FADS2 activity, where linoleic acid (18:2, in numerator) is a precursor to arachidonic acid (20:4, in denominator).4[1], 3[2], 5[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 alter polyunsaturated fatty acid metabolism, which influences lipid levels and inflammatory processes, contributing to phenotypes like hypercholesterolemia, cholelithiasis, and type 2 diabetes.6[1], 7[2], 8[3], 9[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data