carnitine C18:2 to n-acetyl-2-aminooctanoate*

Numerator Metabolite

Structure of linoleoylcarnitine (c18:2)*
Metabolite Accession: GCST90199916
Name: linoleoylcarnitine (c18:2)*
Hmdb Id: HMDB0006469
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJLXQSQYKZWZCB

Denominator Metabolite

Structure of n-acetyl-2-aminooctanoate*
Metabolite Accession: GCST90200183
Name: n-acetyl-2-aminooctanoate*
Hmdb Id: HMDB0059745
Super Pathway: NA
Sub Pathway: NA
Inchikey: JJGNMSOJTSABGA

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.229
Position:
21343833
SE (Ratio):
0.027
Effect Allele:
C
Z-score (Ratio):
8.585
Reference Allele:
A
-log10(P):
-39.244
MAF:
0.155
Beta (Num):
0.125
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
-0.105
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/transport

Denominator Metabolite Explanation:

Fatty acid metabolism

Ratio Explanation:

The ratio may reflect altered hepatic transport by SLCO1B1, which influences substrates like bilirubin, alongside changes in fatty acid metabolism, as carnitine C18:2 is a long-chain acylcarnitine.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function alters bilirubin and lipid levels, including triglycerides, which are established risk factors for coronary atherosclerosis. The gene's role in drug metabolism, like statins, further links it to cardiovascular outcomes and observed phenotypes like high total bilirubin and triglycerides.4[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data