pregnanediol-3-glucuronide to androsterone glucuronide

Numerator Metabolite

Structure of pregnanediol-3-glucuronide
Metabolite Accession: GCST90199917
Name: pregnanediol-3-glucuronide
Hmdb Id: HMDB0010318
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZFFFJLDTCLJDHL

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs4149056

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.295
Position:
21331549
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
13.492
Reference Allele:
T
-log10(P):
-93.854
MAF:
0.157
Beta (Num):
0.253
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.041
SE (Den):
0.018
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

LLM Analysis

Numerator Metabolite Explanation:

Progesterone Metabolism

Denominator Metabolite Explanation:

Androgen Metabolism

Ratio Explanation:

The ratio reflects the balance between progesterone and androgen breakdown products, potentially influenced by SLCO1B1-mediated hepatic clearance of these conjugated steroid hormones.3[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function can impair hepatic uptake of various compounds, including bilirubin and steroid hormones, potentially contributing to the observed phenotypes like altered blood parameters and cardiovascular issues.1[1], 5[2], 6[3], 7[4], 8[5]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data