carboxyethyl-gaba to xanthurenate

Numerator Metabolite

Structure of carboxyethyl-gaba
Metabolite Accession: GCST90199918
Name: carboxyethyl-gaba
Hmdb Id: HMDB0002201
Super Pathway: NA
Sub Pathway: NA
Inchikey: SRGQUICKDUQCKO

Denominator Metabolite

Structure of xanthurenate
Metabolite Accession: GCST90199626
Name: xanthurenate
Hmdb Id: HMDB0000881
Super Pathway: NA
Sub Pathway: NA
Inchikey: FBZONXHGGPHHIY

Associated Genomic Regions

Region: rs1165152

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.245
Position:
25818766
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
11.594
Reference Allele:
G
-log10(P):
-69.898
MAF:
0.445
Beta (Num):
0.137
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.108
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Numerator Pathway(s) (max 10 words): GABA and polyamine metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Denominator Pathway(s) (max 10 words): Tryptophan metabolism (kynurenine pathway).6[1], 7[2]

Ratio Explanation:

Ratio Interpretation (max 25 words): The ratio may reflect altered transport by SLC17A4, potentially impacting two unrelated pathways, as the transporter is known to handle various organic anions.1[1]

Ratio Evidence:

Ratio Evidence Level: metabolites related through biology

Gene Ratio Phenotype Relationship:

Ratio-Phenotype Link (max 50 words): Altered SLC17A4 function likely affects urate transport and thyroid hormone levels, directly impacting the associated phenotypes of uric acid, HbA1c, and various red blood cell indices (MCHC, MCH, Hb, MCV), as thyroid function influences hematopoiesis.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Primary Driver Of Phenotype Link: Gene-centric:[SLC17A4]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data