carboxyethyl-gaba to 4-allylphenol sulfate

Numerator Metabolite

Structure of carboxyethyl-gaba
Metabolite Accession: GCST90199918
Name: carboxyethyl-gaba
Hmdb Id: HMDB0002201
Super Pathway: NA
Sub Pathway: NA
Inchikey: SRGQUICKDUQCKO

Denominator Metabolite

Structure of 4-allylphenol sulfate
Metabolite Accession: GCST90199847
Name: 4-allylphenol sulfate
Hmdb Id: HMDB0170765
Super Pathway: NA
Sub Pathway: NA
Inchikey: KFDHKOFCRYUXLA

Associated Genomic Regions

Region: rs1165152

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.223
Position:
25818766
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
10.577
Reference Allele:
G
-log10(P):
-58.527
MAF:
0.445
Beta (Num):
0.137
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.086
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

GABA metabolism, Polyamine metabolism4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Xenobiotic metabolism, Phenylsulfate metabolism7[1]

Ratio Explanation:

The ratio may reflect altered transport activity by SLC17A4, potentially influencing the balance of a neurotransmitter-related metabolite and a xenobiotic sulfate, though direct transport is unconfirmed.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A4 function likely impacts urate and thyroid hormone transport, contributing to observed associations with serum creatinine, uric acid, and red blood cell indices.8[1], 9[2], 10[3], 11[4] The link to HbA1c may be indirect via effects on erythrocyte biology.12[5]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data