n-palmitoylglycine to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.353
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
20.299
Reference Allele:
C
-log10(P):
-209.253
MAF:
0.208
Beta (Num):
0.336
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.017
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.160
Position:
102075479
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
8.539
Reference Allele:
G
-log10(P):
-38.842
MAF:
0.176
Beta (Num):
0.048
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.112
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid amide metabolism; N-acyl-glycine metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis; Medium-chain fatty acid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

A higher ratio indicates lower FAAH activity, leading to accumulation of N-palmitoylglycine relative to the medium-chain fatty acid 5-dodecenoate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH activity elevates levels of its substrates, which can promote inflammation.10[1] This altered lipid signaling, reflected by the ratio, contributes to the pathogenesis of atherosclerosis, hypercholesterolemia, and related cardiovascular phenotypes by affecting vascular inflammation and lipid metabolism.11[2], 12[3]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data