n-palmitoylglycine to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.178
Position:
102075479
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
9.165
Reference Allele:
G
-log10(P):
-44.448
MAF:
0.176
Beta (Num):
0.048
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.130
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid amide hydrolysis7[1], 8[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation10[1], 11[2]

Ratio Explanation:

This ratio may reflect a balance between fatty acid amide degradation by FAAH and fatty acid oxidation, where reduced FAAH activity could increase n-palmitoylglycine levels.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH activity, due to genetic factors, increases n-palmitoylglycine. Altered n-palmitoylglycine levels are associated with cardiovascular phenotypes like coronary atherosclerosis.12[1] Concurrently, SCD, another associated gene, is directly implicated in atherosclerosis development and lipid metabolism regulation, influencing the risk of coronary artery disease.13[2], 14[3], 15[4]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data