(r)-3-hydroxybutyrylcarnitine to 3-hydroxydecanoate

Numerator Metabolite

Structure of (r)-3-hydroxybutyrylcarnitine
Metabolite Accession: GCST90199930
Name: (r)-3-hydroxybutyrylcarnitine
Hmdb Id: HMDB0013127
Super Pathway: NA
Sub Pathway: NA
Inchikey: UEFRDQSMQXDWTO

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.234
Position:
151879761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
14.730
Reference Allele:
G
-log10(P):
-111.404
MAF:
0.319
Beta (Num):
0.024
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.210
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid and ketone metabolism.3[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 5[2]

Ratio Explanation:

This ratio reflects the balance between fatty acid beta-oxidation and ketone body metabolism; THEM4 can influence the acyl-CoA pools for both pathways.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data