2-aminooctanoate to xanthurenate

Numerator Metabolite

Structure of 2-aminooctanoate
Metabolite Accession: GCST90199937
Name: 2-aminooctanoate
Hmdb Id: HMDB0000991
Super Pathway: NA
Sub Pathway: NA
Inchikey: AKVBCGQVQXPRLD

Denominator Metabolite

Structure of xanthurenate
Metabolite Accession: GCST90199626
Name: xanthurenate
Hmdb Id: HMDB0000881
Super Pathway: NA
Sub Pathway: NA
Inchikey: FBZONXHGGPHHIY

Associated Genomic Regions

Region: rs2762353

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.218
Position:
25794431
SE (Ratio):
0.023
Effect Allele:
A
Z-score (Ratio):
9.631
Reference Allele:
G
-log10(P):
-48.875
MAF:
0.446
Beta (Num):
0.110
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.108
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Amino acid metabolism, Fatty acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Tryptophan metabolism (Kynurenine pathway).7[1], 8[2]

Ratio Explanation:

A higher ratio may suggest altered transport or metabolism, but a direct functional link between 2-aminooctanoate, xanthurenate, and SLC17A4 is not established.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The SLC17A4 gene's primary function as a urate transporter directly explains the association with uric acid levels.1[1], 9[2], 10[3] Its role in thyroid hormone transport could plausibly link to hematological phenotypes, as thyroid hormones influence hematopoiesis.3[4], 11[5]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data