gamma-cehc glucuronide* to gamma-tocopherol/beta-tocopherol

Numerator Metabolite

Structure of gamma-cehc glucuronide*
Metabolite Accession: GCST90199941
Name: gamma-cehc glucuronide*
Hmdb Id: HMDB0242175
Super Pathway: NA
Sub Pathway: NA
Inchikey: NOZSTAZEOBPSBY

Denominator Metabolite

Structure of gamma-tocopherol/beta-tocopherol
Metabolite Accession: GCST90200066
Name: gamma-tocopherol/beta-tocopherol
Hmdb Id: HMDB0006335,HMDB0001492
Super Pathway: NA
Sub Pathway: NA
Inchikey: WGVKWNUPNGFDFJ

Associated Genomic Regions

Region: rs2108622

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.297
Position:
15990431
SE (Ratio):
0.024
Effect Allele:
T
Z-score (Ratio):
-12.166
Reference Allele:
C
-log10(P):
-76.742
MAF:
0.274
Beta (Num):
-0.211
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.086
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H4 OR10H1 OR10H5

LLM Analysis

Numerator Metabolite Explanation:

Vitamin E degradation.7[1], 4[2]

Denominator Metabolite Explanation:

Vitamin E metabolism.4[1], 8[2], 9[3]

Ratio Explanation:

The ratio of gamma-cehc glucuronide to its precursor gamma-tocopherol reflects the metabolic activity of CYP4F2, where higher values indicate increased degradation of gamma-tocopherol.7[1], 4[2], 2[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced CYP4F2 activity, potentially due to the missense variant, leads to decreased gamma-tocopherol degradation, altering the ratio and is associated with coronary artery disease, possibly through altered vitamin K or eicosanoid metabolism.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data