sphingomyelin (d18:2/16:0, d18:1/16:1)* to 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*

Numerator Metabolite

Metabolite Accession: GCST90199947
Name: sphingomyelin (d18:2/16:0, d18:1/16:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Associated Genomic Regions

Region: rs58664468

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
-0.184
Position:
11088007
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
-8.567
Reference Allele:
C
-log10(P):
-39.081
MAF:
0.231
Beta (Num):
-0.075
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.109
SE (Den):
0.018
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
SMIM13 ERVFRD-1 ELOVL2 NEDD9 SYCP2L

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism, Ceramide synthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid elongation.3[1], 6[2]

Ratio Explanation:

The ratio may reflect ELOVL2 activity, contrasting sphingolipids with phosphatidylcholines containing the ELOVL2-product arachidonic acid, indicating a shift in fatty acid allocation.3[1], 7[2], 8[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype information was provided, so a causal link between the gene, metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data