n2,n5-diacetylornithine to hydroxy-cmpf*

Numerator Metabolite

Structure of n2,n5-diacetylornithine
Metabolite Accession: GCST90199954
Name: n2,n5-diacetylornithine
Hmdb Id: HMDB0240345
Super Pathway: NA
Sub Pathway: NA
Inchikey: XUYANFPPYJSBPU

Denominator Metabolite

Metabolite Accession: GCST90200154
Name: hydroxy-cmpf*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.187
Position:
25809069
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-9.196
Reference Allele:
G
-log10(P):
-44.740
MAF:
0.444
Beta (Num):
-0.077
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.110
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Urea cycle, Polyamine metabolism.7[1]

Denominator Metabolite Explanation:

Tryptophan metabolism, Fatty acid metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio may reflect altered renal or intestinal clearance of uremic toxins, influenced by SLC17A4's function as a polyspecific organic anion transporter.4[1], 11[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 missense variant likely alters its function as a urate and organic anion transporter.4[1], 12[2] This altered transport could affect serum levels of uric acid and other metabolites like those in the ratio, leading to the observed phenotypes related to renal function and hematopoiesis.13[3]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data