ferulic acid 4-sulfate to phenylacetylglutamate

Numerator Metabolite

Structure of ferulic acid 4-sulfate
Metabolite Accession: GCST90199955
Name: ferulic acid 4-sulfate
Hmdb Id: HMDB0029200
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZPATWACAAOHTJ

Denominator Metabolite

Structure of phenylacetylglutamate
Metabolite Accession: GCST90200069
Name: phenylacetylglutamate
Hmdb Id: HMDB0059772
Super Pathway: NA
Sub Pathway: NA
Inchikey: PTSRBZOZSRJCKX

Associated Genomic Regions

Region: rs2762353

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.463
Position:
25794431
SE (Ratio):
0.023
Effect Allele:
A
Z-score (Ratio):
-19.744
Reference Allele:
G
-log10(P):
-198.129
MAF:
0.438
Beta (Num):
-0.302
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.161
SE (Den):
0.017
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, sulfation.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Phenylalanine and xenobiotic metabolism.8[1], 9[2], 10[3], 11[4]

Ratio Explanation:

The ratio likely reflects altered transport activity by SLC17A4, affecting the clearance of ferulic acid 4-sulfate and the uremic toxin phenylacetylglutamate.3[1], 4[2], 12[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A4 function likely affects the excretion of its substrates, including urate and phenylacetylglutamate, leading to changes in serum creatinine and uric acid, which are established kidney function markers, and downstream effects on hematological traits.13[1], 14[2], 15[3]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data