ferulic acid 4-sulfate to caffeic acid sulfate

Numerator Metabolite

Structure of ferulic acid 4-sulfate
Metabolite Accession: GCST90199955
Name: ferulic acid 4-sulfate
Hmdb Id: HMDB0029200
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZPATWACAAOHTJ

Denominator Metabolite

Structure of caffeic acid sulfate
Metabolite Accession: GCST90200093
Name: caffeic acid sulfate
Hmdb Id: HMDB0041708
Super Pathway: NA
Sub Pathway: NA
Inchikey: SNVAIAITQIIEMQ

Associated Genomic Regions

Region: rs2762353

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.381
Position:
25794431
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-25.119
Reference Allele:
G
-log10(P):
-318.921
MAF:
0.438
Beta (Num):
-0.302
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.079
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Phenylpropanoid metabolism.5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Phenylpropanoid metabolism.5[1], 6[2], 7[3], 8[4]

Ratio Explanation:

Ferulic acid is a methylated product of caffeic acid; the ratio may reflect upstream enzymatic activity or differential transport by SLC17A4.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 gene's role as a transporter for urate directly explains the association with uric acid levels.9[1], 2[2], 10[3] Links to hematological traits (MCHC, MCH, Ht, Hb) are observed, potentially secondary to SLC17A4's role in nutrient transport or renal/thyroid function.11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data