ferulic acid 4-sulfate to decadienedioic acid (c10:2-dc)**

Numerator Metabolite

Structure of ferulic acid 4-sulfate
Metabolite Accession: GCST90199955
Name: ferulic acid 4-sulfate
Hmdb Id: HMDB0029200
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZPATWACAAOHTJ

Denominator Metabolite

Structure of decadienedioic acid (c10:2-dc)**
Metabolite Accession: GCST90200700
Name: decadienedioic acid (c10:2-dc)**
Hmdb Id: HMDB0242172
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRWVXIATCBRYHA

Associated Genomic Regions

Region: rs2762353

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.465
Position:
25794431
SE (Ratio):
0.023
Effect Allele:
A
Z-score (Ratio):
-20.058
Reference Allele:
G
-log10(P):
-204.385
MAF:
0.438
Beta (Num):
-0.302
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.163
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Phenylpropanoid metabolism.7[1], 8[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.9[1]

Ratio Explanation:

The ratio may reflect differential renal or intestinal clearance of unrelated organic acids influenced by SLC17A4 activity, but the connection is indirect.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the SLC17A4 urate/thyroid hormone transporter is associated with altered red blood cell indices (MCHC, MCH, Hb, Ht, MCV) and urate levels, likely through pleiotropic effects on erythropoiesis and renal function.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data