1-linolenoyl-gpc (18:3)* to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Structure of 1-linolenoyl-gpc (18:3)*
Metabolite Accession: GCST90199958
Name: 1-linolenoyl-gpc (18:3)*
Hmdb Id: HMDB0010388
Super Pathway: NA
Sub Pathway: NA
Inchikey: WKQNRCYKYCKESD

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs964184

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.174
Position:
116648917
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
-8.026
Reference Allele:
C
-log10(P):
-34.533
MAF:
0.131
Beta (Num):
-0.072
Novel Locus:
Yes ✔️
SE (Num):
0.023
Beta (Den):
0.103
SE (Den):
0.022
No CNV overlap
rQTL cluster:
248
Reaction Distance:
NA
Closest Genes:
ZNF259 BUD13 APOA5 APOA4 APOC3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Linolenic acid metabolism.3[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.4[1], 5[2], 6[3]

Ratio Explanation:

The ratio reflects the balance between a polyunsaturated fatty acid-containing lysophosphatidylcholine and a saturated fatty acid-containing lysophosphatidylethanolamine, influenced by apolipoprotein-mediated lipid transport.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in the APOA5 gene cluster alter triglyceride and lipoprotein metabolism.1[1], 7[2], 8[3] This dysregulation impacts the balance of circulating lysophospholipids, which is associated with dyslipidemia and an increased risk for coronary atherosclerosis and myocardial infarction.7[4], 9[5]

Phenotype Driver:

Gene-centric:APOA5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data