etiocholanolone glucuronide to epiandrosterone sulfate

Numerator Metabolite

Structure of etiocholanolone glucuronide
Metabolite Accession: GCST90199964
Name: etiocholanolone glucuronide
Hmdb Id: HMDB0004484
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Denominator Metabolite

Structure of epiandrosterone sulfate
Metabolite Accession: GCST90199752
Name: epiandrosterone sulfate
Hmdb Id: HMDB0062657
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs72790679

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.613
Position:
31654155
SE (Ratio):
0.060
Effect Allele:
A
Z-score (Ratio):
10.288
Reference Allele:
G
-log10(P):
-55.492
MAF:
0.018
Beta (Num):
0.417
Novel Locus:
No
SE (Num):
0.058
Beta (Den):
-0.196
SE (Den):
0.055
No CNV overlap
rQTL cluster:
150
Reaction Distance:
NA
Closest Genes:
XDH EHD3 CAPN14 GALNT14 MEMO1

Region: rs113017476

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.484
Position:
31989359
SE (Ratio):
0.043
Effect Allele:
A
Z-score (Ratio):
11.360
Reference Allele:
G
-log10(P):
-67.185
MAF:
0.036
Beta (Num):
0.285
Novel Locus:
No
SE (Num):
0.041
Beta (Den):
-0.199
SE (Den):
0.039
No CNV overlap
rQTL cluster:
149
Reaction Distance:
NA
Closest Genes:
MEMO1 DPY30 SPAST XDH SLC30A6

Region: rs72800808

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.394
Position:
32691615
SE (Ratio):
0.052
Effect Allele:
A
Z-score (Ratio):
7.572
Reference Allele:
G
-log10(P):
-30.932
MAF:
0.024
Beta (Num):
0.257
Novel Locus:
Yes ✔️
SE (Num):
0.050
Beta (Den):
-0.137
SE (Den):
0.048
No CNV overlap
rQTL cluster:
150
Reaction Distance:
NA
Closest Genes:
BIRC6 YIPF4 TTC27 NLRC4 SLC30A6

Region: rs976058

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Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
-0.150
Position:
69341487
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-9.183
Reference Allele:
T
-log10(P):
-44.616
MAF:
0.399
Beta (Num):
-0.055
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.095
SE (Den):
0.015
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 YTHDC1 UGT2B15 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism, glucuronidation.3[1], 4[2]

Denominator Metabolite Explanation:

Androgen metabolism, sulfation.5[1], 6[2]

Ratio Explanation:

Ratio reflects activity of glucuronidation (e.g., UGT2B17) relative to sulfation pathways in androgen metabolism, impacting clearance of etiocholanolone versus epiandrosterone.7[1], 8[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in UGT genes alters androgen conjugation, reflected by the ratio.7[1], 2[2] This shift in steroid metabolism likely modulates hepatic lipoprotein synthesis, contributing to dyslipidemia and altered cholesterol levels.9[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Metabolite-centric[etiocholanolone glucuronide, epiandrosterone sulfate]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data