etiocholanolone glucuronide to androstenediol (3beta,17beta) disulfate (2)

Numerator Metabolite

Structure of etiocholanolone glucuronide
Metabolite Accession: GCST90199964
Name: etiocholanolone glucuronide
Hmdb Id: HMDB0004484
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Denominator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Associated Genomic Regions

Region: rs62142080

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
2
Beta (Ratio):
-0.152
Position:
32182528
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-9.606
Reference Allele:
T
-log10(P):
-48.641
MAF:
0.391
Beta (Num):
-0.112
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.040
SE (Den):
0.014
No CNV overlap
rQTL cluster:
151
Reaction Distance:
NA
Closest Genes:
MEMO1 DPY30 SPAST SLC30A6 NLRC4

Region: rs1165196

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
-0.140
Position:
25813150
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
-9.056
Reference Allele:
A
-log10(P):
-43.447
MAF:
0.444
Beta (Num):
-0.050
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.090
SE (Den):
0.014
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism; Steroid hormone biosynthesis. 6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Androgen metabolism; Steroid hormone biosynthesis. 9[1], 10[2], 11[3]

Ratio Explanation:

The ratio reflects the balance between two major androgen inactivation pathways: glucuronidation (numerator) and sulfation (denominator), potentially influenced by inflammation via NLRC4-mediated cytokine activity. 12[1], 7[2], 13[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in NLRC4 likely modulates inflammasome activity, which can directly contribute to 'Pain in limb' via inflammatory signaling. 3[1], 14[2]This systemic inflammation may also alter steroid hormone metabolism, affecting the ratio and androgen-sensitive hematopoietic and metabolic phenotypes. 15[3], 16[4], 17[5], 12[6], 18[7]

Phenotype Driver:

Gene-centric:NLRC4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data