etiocholanolone glucuronide to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2)

Numerator Metabolite

Structure of etiocholanolone glucuronide
Metabolite Accession: GCST90199964
Name: etiocholanolone glucuronide
Hmdb Id: HMDB0004484
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Denominator Metabolite

Metabolite Accession: GCST90199854
Name: 5alpha-pregnan-3beta,20alpha-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs76712439

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.536
Position:
31914921
SE (Ratio):
0.049
Effect Allele:
T
Z-score (Ratio):
11.031
Reference Allele:
C
-log10(P):
-63.481
MAF:
0.036
Beta (Num):
0.282
Novel Locus:
No
SE (Num):
0.041
Beta (Den):
-0.254
SE (Den):
0.042
No CNV overlap
rQTL cluster:
149
Reaction Distance:
NA
Closest Genes:
MEMO1 DPY30 XDH SPAST EHD3

Region: rs72787555

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.463
Position:
32922317
SE (Ratio):
0.049
Effect Allele:
G
Z-score (Ratio):
9.466
Reference Allele:
A
-log10(P):
-47.286
MAF:
0.035
Beta (Num):
0.259
Novel Locus:
Yes ✔️
SE (Num):
0.042
Beta (Den):
-0.204
SE (Den):
0.042
No CNV overlap
rQTL cluster:
149
Reaction Distance:
NA
Closest Genes:
TTC27 BIRC6 LTBP1 YIPF4 NLRC4

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism, Steroid hormone biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Progesterone metabolism, Steroid hormone biosynthesis.6[1], 7[2]

Ratio Explanation:

The ratio of an androgen metabolite (etiocholanolone) to a progesterone metabolite (pregnanediol) may reflect steroidogenic balance, but its association with SPAST is not direct.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data