etiocholanolone glucuronide to 5alpha-androstan-3beta,17beta-diol monosulfate (2)

Numerator Metabolite

Structure of etiocholanolone glucuronide
Metabolite Accession: GCST90199964
Name: etiocholanolone glucuronide
Hmdb Id: HMDB0004484
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Denominator Metabolite

Metabolite Accession: GCST90199855
Name: 5alpha-androstan-3beta,17beta-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs112881196

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.576
Position:
31982811
SE (Ratio):
0.050
Effect Allele:
G
Z-score (Ratio):
11.610
Reference Allele:
C
-log10(P):
-70.078
MAF:
0.035
Beta (Num):
0.275
Novel Locus:
No
SE (Num):
0.042
Beta (Den):
-0.300
SE (Den):
0.043
No CNV overlap
rQTL cluster:
149
Reaction Distance:
NA
Closest Genes:
MEMO1 DPY30 SPAST XDH SLC30A6

Region: rs72789842

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.437
Position:
33146564
SE (Ratio):
0.055
Effect Allele:
T
Z-score (Ratio):
7.964
Reference Allele:
C
-log10(P):
-34.031
MAF:
0.029
Beta (Num):
0.182
Novel Locus:
Yes ✔️
SE (Num):
0.046
Beta (Den):
-0.255
SE (Den):
0.048
No CNV overlap
rQTL cluster:
149
Reaction Distance:
NA
Closest Genes:
LTBP1 TTC27 BIRC6 RASGRP3 YIPF4

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Estrogen Metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Androgen and Estrogen Metabolism.5[1], 6[2]

Ratio Explanation:

This ratio reflects the balance between glucuronidation (numerator) and sulfation (denominator), two key pathways for androgen metabolite clearance, influenced by UGT2B15/UGT2B17 activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variations in UGT2B15/UGT2B17 genes alter steroid hormone glucuronidation, affecting androgen metabolite levels.1[1], 7[2] This shift in steroid metabolism can influence liver function and is associated with changes in lipid profiles and disorders of lipoprotein metabolism.8[3], 7[4], 9[5]

Phenotype Driver:

Gene-centric:UGT2B15/UGT2B17

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data