etiocholanolone glucuronide to 5alpha-androstan-3alpha,17beta-diol monosulfate (1)

Numerator Metabolite

Structure of etiocholanolone glucuronide
Metabolite Accession: GCST90199964
Name: etiocholanolone glucuronide
Hmdb Id: HMDB0004484
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Denominator Metabolite

Metabolite Accession: GCST90199858
Name: 5alpha-androstan-3alpha,17beta-diol monosulfate (1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs115332425

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.726
Position:
31879296
SE (Ratio):
0.075
Effect Allele:
G
Z-score (Ratio):
9.638
Reference Allele:
T
-log10(P):
-48.952
MAF:
0.016
Beta (Num):
0.453
Novel Locus:
No
SE (Num):
0.061
Beta (Den):
-0.274
SE (Den):
0.063
No CNV overlap
rQTL cluster:
150
Reaction Distance:
NA
Closest Genes:
MEMO1 DPY30 XDH EHD3 SPAST

Region: rs112881196

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.607
Position:
31982811
SE (Ratio):
0.051
Effect Allele:
G
Z-score (Ratio):
11.941
Reference Allele:
C
-log10(P):
-74.000
MAF:
0.035
Beta (Num):
0.275
Novel Locus:
No
SE (Num):
0.042
Beta (Den):
-0.332
SE (Den):
0.042
No CNV overlap
rQTL cluster:
149
Reaction Distance:
NA
Closest Genes:
MEMO1 DPY30 SPAST XDH SLC30A6

LLM Analysis

Numerator Metabolite Explanation:

Androgen and progestin metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Androgen and progestin metabolism.5[1], 6[2]

Ratio Explanation:

The ratio reflects the balance between glucuronidation and sulfation pathways in androgen metabolism, with UGT enzymes influencing the numerator.1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in UGT2B17, an enzyme that glucuronidates androgens, alters steroid hormone clearance.1[1], 8[2], 9[3] This change in androgen metabolism likely impacts lipid profiles, as androgen levels are linked to lipoprotein metabolism, explaining the association with lipid disorders.10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:UGT2B17

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data