etiocholanolone glucuronide to andro steroid monosulfate c19h28o6s (1)*

Numerator Metabolite

Structure of etiocholanolone glucuronide
Metabolite Accession: GCST90199964
Name: etiocholanolone glucuronide
Hmdb Id: HMDB0004484
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Denominator Metabolite

Structure of andro steroid monosulfate c19h28o6s (1)*
Metabolite Accession: GCST90199860
Name: andro steroid monosulfate c19h28o6s (1)*
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-1.133
Position:
99075038
SE (Ratio):
0.052
Effect Allele:
C
Z-score (Ratio):
-21.791
Reference Allele:
T
-log10(P):
-240.725
MAF:
0.032
Beta (Num):
-0.304
Novel Locus:
No
SE (Num):
0.043
Beta (Den):
0.829
SE (Den):
0.041
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism, steroid glucuronidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Androgen metabolism, steroid sulfation.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects the balance between two major androgen clearance pathways: glucuronidation (numerator) and sulfation (denominator), indicating relative activity of conjugation enzymes.10[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants colocalized with the sulfotransferase gene GAL3ST4 likely alter steroid hormone conjugation balance.1[1], 2[2] This altered steroid signaling can plausibly affect metabolic (BMI, Uric acid) and inflammatory (CRP, WBC) phenotypes, which are known to be steroid-responsive.11[3], 12[4], 13[5]

Phenotype Driver:

Metabolite-centric[both]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data