etiocholanolone glucuronide to androsterone sulfate

Numerator Metabolite

Structure of etiocholanolone glucuronide
Metabolite Accession: GCST90199964
Name: etiocholanolone glucuronide
Hmdb Id: HMDB0004484
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Denominator Metabolite

Structure of androsterone sulfate
Metabolite Accession: GCST90200674
Name: androsterone sulfate
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs72790679

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.709
Position:
31654155
SE (Ratio):
0.066
Effect Allele:
A
Z-score (Ratio):
10.780
Reference Allele:
G
-log10(P):
-60.714
MAF:
0.018
Beta (Num):
0.417
Novel Locus:
No
SE (Num):
0.058
Beta (Den):
-0.292
SE (Den):
0.056
No CNV overlap
rQTL cluster:
150
Reaction Distance:
NA
Closest Genes:
XDH EHD3 CAPN14 GALNT14 MEMO1

Region: rs113017476

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.546
Position:
31989359
SE (Ratio):
0.047
Effect Allele:
A
Z-score (Ratio):
11.587
Reference Allele:
G
-log10(P):
-69.809
MAF:
0.036
Beta (Num):
0.285
Novel Locus:
No
SE (Num):
0.041
Beta (Den):
-0.261
SE (Den):
0.040
No CNV overlap
rQTL cluster:
149
Reaction Distance:
NA
Closest Genes:
MEMO1 DPY30 SPAST XDH SLC30A6

Region: rs74364753

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.612
Position:
32693881
SE (Ratio):
0.069
Effect Allele:
G
Z-score (Ratio):
8.911
Reference Allele:
C
-log10(P):
-42.131
MAF:
0.016
Beta (Num):
0.385
Novel Locus:
No
SE (Num):
0.060
Beta (Den):
-0.227
SE (Den):
0.059
No CNV overlap
rQTL cluster:
150
Reaction Distance:
NA
Closest Genes:
BIRC6 YIPF4 TTC27 NLRC4 SLC30A6

Region: rs9884390

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Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.249
Position:
69373407
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
11.766
Reference Allele:
T
-log10(P):
-71.913
MAF:
0.222
Beta (Num):
0.073
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.177
SE (Den):
0.018
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 UGT2B15 YTHDC1 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism, Glucuronidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Androgen metabolism, Sulfation.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the balance between two major androgen hormone breakdown pathways, glucuronidation and sulfation, with genetic factors like UGT2B15/17 influencing this balance.10[1], 11[2], 12[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The association of UGT2B15/17, key enzymes in androgen glucuronidation, with this ratio and lipid-related phenotypes in FinnGen suggests a link between androgen metabolism and lipid homeostasis. Altered steroid hormone levels, influenced by the activity of these enzymes, could be the causal link to disorders of lipoprotein metabolism.

Phenotype Driver:

Gene-centric:UGT2B15/UGT2B17

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data