etiocholanolone glucuronide to androsterone glucuronide

Numerator Metabolite

Structure of etiocholanolone glucuronide
Metabolite Accession: GCST90199964
Name: etiocholanolone glucuronide
Hmdb Id: HMDB0004484
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs72790679

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.748
Position:
31654155
SE (Ratio):
0.050
Effect Allele:
A
Z-score (Ratio):
14.969
Reference Allele:
G
-log10(P):
-114.972
MAF:
0.018
Beta (Num):
0.417
Novel Locus:
No
SE (Num):
0.058
Beta (Den):
-0.331
SE (Den):
0.051
No CNV overlap
rQTL cluster:
150
Reaction Distance:
NA
Closest Genes:
XDH EHD3 CAPN14 GALNT14 MEMO1

Region: rs113017476

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.617
Position:
31989359
SE (Ratio):
0.036
Effect Allele:
A
Z-score (Ratio):
17.243
Reference Allele:
G
-log10(P):
-151.735
MAF:
0.036
Beta (Num):
0.285
Novel Locus:
No
SE (Num):
0.041
Beta (Den):
-0.332
SE (Den):
0.037
No CNV overlap
rQTL cluster:
149
Reaction Distance:
NA
Closest Genes:
MEMO1 DPY30 SPAST XDH SLC30A6

Region: rs72800809

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.689
Position:
32695880
SE (Ratio):
0.052
Effect Allele:
C
Z-score (Ratio):
13.252
Reference Allele:
G
-log10(P):
-90.626
MAF:
0.016
Beta (Num):
0.380
Novel Locus:
No
SE (Num):
0.060
Beta (Den):
-0.309
SE (Den):
0.053
No CNV overlap
rQTL cluster:
150
Reaction Distance:
NA
Closest Genes:
BIRC6 YIPF4 TTC27 NLRC4 SLC30A6

Region: rs113425774

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.264
Position:
33004063
SE (Ratio):
0.028
Effect Allele:
A
Z-score (Ratio):
9.405
Reference Allele:
G
-log10(P):
-46.704
MAF:
0.058
Beta (Num):
0.118
Novel Locus:
No
SE (Num):
0.033
Beta (Den):
-0.146
SE (Den):
0.028
No CNV overlap
rQTL cluster:
149
Reaction Distance:
NA
Closest Genes:
TTC27 BIRC6 LTBP1 YIPF4 NLRC4

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism, glucuronidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Androgen metabolism, glucuronidation.7[1], 4[2], 8[3]

Ratio Explanation:

This ratio reflects the balance between 5β-reductase (producing etiocholanolone) and 5α-reductase (producing androsterone) activity in androgen metabolism.

Ratio Evidence:

9[1], 10[2], 11[3] metabolites related through biology

Gene Ratio Phenotype Relationship:

YIPF4's role in Golgi trafficking could influence the processing of steroidogenic enzymes, altering the relative 5α/5β-reductase activities and thus the etiocholanolone/androsterone ratio; no phenotype is provided.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data