1-(1-enyl-oleoyl)-gpe (p-18:1)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Metabolite Accession: GCST90199966
Name: 1-(1-enyl-oleoyl)-gpe (p-18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.182
Position:
61569830
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
-10.100
Reference Allele:
C
-log10(P):
-53.555
MAF:
0.340
Beta (Num):
-0.053
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, ether lipid metabolism.3[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, linoleic acid metabolism.4[1]

Ratio Explanation:

This ratio reflects FADS1/FADS2 desaturase activity, influencing the balance between oleoyl (18:1) and linoleoyl (18:2) derived lipids in different phospholipid classes.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants alter polyunsaturated fatty acid metabolism, impacting the balance of pro- and anti-inflammatory lipid mediators.5[1], 6[2] This dysregulation is linked to inflammatory conditions like IBD and asthma, and metabolic disorders like hypercholesterolemia and type 2 diabetes.5[3], 2[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data