1-(1-enyl-oleoyl)-gpe (p-18:1)* to 1-(1-enyl-palmitoyl)-gpc (p-16:0)*

Numerator Metabolite

Metabolite Accession: GCST90199966
Name: 1-(1-enyl-oleoyl)-gpe (p-18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Associated Genomic Regions

Region: rs1885041

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
14
Beta (Ratio):
0.121
Position:
67976325
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
8.515
Reference Allele:
C
-log10(P):
-38.630
MAF:
0.476
Beta (Num):
0.024
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.097
SE (Den):
0.016
No CNV overlap
rQTL cluster:
46
Reaction Distance:
NA
Closest Genes:
TMEM229B PLEKHH1 PIGH PLEK2 ARG2

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis.3[1], 4[2], 5[3]

Ratio Explanation:

The ratio reflects the relative abundance of an ethanolamine plasmalogen to a choline plasmalogen, both key components of cell membranes with distinct tissue distributions.6[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data