1-(1-enyl-oleoyl)-gpe (p-18:1)* to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*

Numerator Metabolite

Metabolite Accession: GCST90199966
Name: 1-(1-enyl-oleoyl)-gpe (p-18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Associated Genomic Regions

Region: rs174547

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.221
Position:
61570783
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-12.657
Reference Allele:
T
-log10(P):
-82.867
MAF:
0.340
Beta (Num):
-0.053
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.167
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis3[1], 4[2]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis5[1]

Ratio Explanation:

This ratio may reflect FADS1/FADS2 activity, where lower activity leads to an accumulation of the oleoyl (18:1) numerator relative to the linoleoyl (18:2) denominator.6[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants influence PUFA levels, impacting inflammatory and metabolic phenotypes like asthma, cholelithiasis, and type 2 diabetes, all associated with this ratio.1[1], 7[2]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data