octadecenedioylcarnitine (c18:1-dc)* to eicosenoylcarnitine (c20:1)*

Numerator Metabolite

Structure of octadecenedioylcarnitine (c18:1-dc)*
Metabolite Accession: GCST90199970
Name: octadecenedioylcarnitine (c18:1-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CYPBWZKNUDFJJE

Denominator Metabolite

Structure of eicosenoylcarnitine (c20:1)*
Metabolite Accession: GCST90200148
Name: eicosenoylcarnitine (c20:1)*
Hmdb Id: HMDB0240746
Super Pathway: NA
Sub Pathway: NA
Inchikey: PVOQPLSKYNZHOT

Associated Genomic Regions

Region: rs2108622

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.219
Position:
15990431
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
-12.475
Reference Allele:
C
-log10(P):
-80.565
MAF:
0.297
Beta (Num):
-0.149
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.070
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H4 OR10H1 OR10H5

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.

Ratio Explanation:

The ratio reflects the balance between omega-oxidation (numerator) and beta-oxidation (denominator). Elevated levels may suggest increased omega-oxidation, possibly due to impaired beta-oxidation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

CYP4F2 variants may alter its enzymatic activity, impacting the metabolism of fatty acids.5[1] This could influence the risk of coronary atherosclerosis and ischaemic heart disease.6[2], 7[3], 8[4]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data