9-hydroxystearate to nonadecanoate (19:0)

Numerator Metabolite

Structure of 9-hydroxystearate
Metabolite Accession: GCST90199974
Name: 9-hydroxystearate
Hmdb Id: HMDB0061661
Super Pathway: NA
Sub Pathway: NA
Inchikey: RKHXDCVAPIMDMG

Denominator Metabolite

Structure of nonadecanoate (19:0)
Metabolite Accession: GCST90200451
Name: nonadecanoate (19:0)
Hmdb Id: HMDB0000772
Super Pathway: NA
Sub Pathway: NA
Inchikey: ISYWECDDZWTKFF

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.163
Position:
102075479
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
-8.380
Reference Allele:
G
-log10(P):
-37.474
MAF:
0.173
Beta (Num):
-0.115
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.048
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid hydroxylation

Denominator Metabolite Explanation:

Fatty acid metabolism3[1], 4[2]

Ratio Explanation:

This ratio may reflect SCD-independent fatty acid modification, where higher values suggest increased hydroxylation relative to the odd-chain saturated fatty acid pool.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SCD and ABCC2 function can disrupt fatty acid balance and transport, contributing to dyslipidemia and inflammation, which are key factors in the development of atherosclerosis, myocardial infarction, and hypertension.1[1], 5[2], 6[3]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data