sphingomyelin (d18:2/14:0, d18:1/14:1)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Metabolite Accession: GCST90199975
Name: sphingomyelin (d18:2/14:0, d18:1/14:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs102274

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.214
Position:
61557826
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
-11.282
Reference Allele:
T
-log10(P):
-66.304
MAF:
0.340
Beta (Num):
-0.088
Novel Locus:
No
SE (Num):
0.013
Beta (Den):
0.126
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid synthesis3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects FADS1/FADS2 activity, which influences the fatty acid composition of both sphingolipids and glycerophospholipids, thus connecting two major lipid metabolic pathways.9[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters PUFA levels, impacting lipid profiles (cholesterol, triglycerides) and inflammatory responses.1[1], 2[2], 10[3] This dysregulation is linked to cardiometabolic and inflammatory phenotypes like hypercholesterolemia, cholelithiasis, and asthma, with abnormal lipid metabolism being a key factor in gallstone formation.11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data