1-dihomo-linolenylglycerol (20:3) to 1-arachidonylglycerol (20:4)

Numerator Metabolite

Metabolite Accession: GCST90199976
Name: 1-dihomo-linolenylglycerol (20:3)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-arachidonylglycerol (20:4)
Metabolite Accession: GCST90199770
Name: 1-arachidonylglycerol (20:4)
Hmdb Id: HMDB0011578
Super Pathway: NA
Sub Pathway: NA
Inchikey: DCPCOKIYJYGMDN

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.322
Position:
61588305
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
19.967
Reference Allele:
A
-log10(P):
-202.566
MAF:
0.351
Beta (Num):
0.051
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.271
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid metabolism.3[1], 4[2]

Ratio Explanation:

This ratio reflects the enzymatic efficiency of FADS1 in converting dihomo-linolenylglycerol to arachidonylglycerol, a key step in fatty acid metabolism.1[1], 5[2]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity, indicated by an increased ratio, alters fatty acid profiles, which is linked to inflammatory and metabolic disorders like cholelithiasis and hypercholesterolemia.6[1], 7[2], 8[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data